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Case 100

A 67 year old male with a 3.4 cm lung mass.


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  1. What's your impression?

    A: Benign reactive changes

    B: Sclerosing pneumocytoma

    C: Histocytic lesion

    D: Sarcoma with clear cell features

    E: Carcinoma


IHC work up

  • Pan-Keratin

  • TTF1

  • CK7

  • CK20

You can vote for more than one answer.


  1. If the tumor is positive for PAX8 and keratin, what's the most likely diagnosis?


Answer

This is a case of metastatic clear cell carcinoma, in real like you often know the history and with this morphology, clear cell carcinoma is definitely on the differential. However, as an unknown case, it's tough.

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD

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