Case 114

A duodenal biopsy was performed on a 77 year old male.

1. What's the 5 year survival rate of this tumor?

   A: 60-70%

   B: 80-90%

   C: 10-20%

   D: 20-40%

Answer

Tumor Type

5-Year Survival Rate

Key Findings

Signet Ring Cell Carcinoma (SRC)

~20–40% overall

- Survival depends on stage at diagnosis and extent of invasion. - Early-stage SRC may have survival close to conventional adenocarcinoma. - Advanced-stage SRC shows much worse prognosis.

Poorly Cohesive Carcinoma (PCC)

~23–35% overall

- PCC is a broader category including SRC subtype. - Tends to present at an advanced stage, contributing to lower survival. - Higher incidence of peritoneal metastasis and chemoresistance.

Reference: https://tumourclassification.iarc.who.int/chaptercontent/31/29

Case credit: UCSD pathology

Author: Wangpan Jackson Shi, MD