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Case 20

Updated: Jan 23

A 25-year-old female presented with oral progestin use and found to have a large cervical polyp.



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  1. What is the diagnosis?

    A: endometrioid carcinoma

    B: atypical hyperplasia/EIN

    C: microglandular hyperplasia

    D: atypical mucinous glandular proliferation

    E: microglandular hyperplasia like endometrioid carcinoma



Answer

The correct answer is C. Microglandular hyperplasia is a benign proliferation that classically seen in young female with history of OCP use. It's originated from reserve cell hyperplasia that undergoes glandular differentiation. Subnuclear vacuolation and reserve cell hyperplasia are two helpful features in this case. It showed a inflamed background with sometimes intraluminal neutrophils. p63 and CK17 can highlight the reserve cell layer, also MGH has low Ki-67 in contrast to microglandular hyperplasia like endometrioid carcinoma.




Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD

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