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Case 22

Updated: Jan 23

A 60-year-old man with obstructive jaundice. A Bile duct biopsy was performed:


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What's your diagnosis?

A: Stent effect and reactive atypia

B: Reactive atypia due to inflammation

C: Adenocarcinoma

D: Atypia, not carcinoma yet


Answer

The correct answer is C. This is a case of moderately differentiated adenocarcinoma likely cholangiosarcoma. It has malignant cytology: pleomorphism, prominent nucleoli, and irregular nucleus membrane.

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD


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