Case 80

A 55-year-old female with a breast mass.

1. What's the diagnosis?

   A: UDH

   B: Intraductal papilloma

   C: ADH

   D: DCIS

Answer

The correct answer is DCIS, this is micropapillary DCIS. The nuclear grading is grade 3. Papillary fronds and tufts lacking fibrovascular cores projecting into duct lumen. Papillae often have club shaped cells comprising the micropapillae are uniform in appearance. Tips of fronds may fuse, forming bridges and arcades; For high grade nuclei you will see prominient nucleoli and >2.5 size of lymphocytes.

Reference: https://www.pathologyoutlines.com/topic/breastmalignantdcis.html

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD